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Anticholinergic poisoning: cool the patient, not the clues

Educational use only. Not clinically reviewed

29-year-old woman for calm hyperthermia, delirium, ECG, supportive-care, antidote-boundary, reassessment, and handoff practice. About 6 simulated minutes.

What you will practise

  • Reconcile product, clock, delirium, temperature, dryness, retention, ECG, and the whole patient.
  • Recognize the central and peripheral anticholinergic pattern without mnemonic-, temperature-, pupil-, or dryness-only closure.
  • Activate resuscitation, cooling, airway, toxicology, monitoring, and compassionate safety ownership.
  • Review supplied temperature, CNS, ECG, renal, CK, retention, and differential evidence.
  • Record bounded qualified cooling, support, sedation, surveillance, and antidote-eligibility intent, then review a strict later report.
  • Hand off rebound delirium, hyperthermia, retention, rhabdomyolysis, seizure, coingestion, and active risk.

Review and sources

Not clinically reviewed. No clinician has signed this scenario.

  • American Heart Association. 2025 Guidelines for CPR and ECC. Part 10, Section 16.2, Adults with Life-Threatening Hyperthermia. Consulted 2026-08-26.
  • National Library of Medicine. StatPearls: Anticholinergic Toxicity. Consulted 2026-08-26.

Every scenario in this module

Open Sim Lab is an educational simulator, not for clinical use. It is not a clinical decision-support tool, not a dosing calculator, and is not validated for any decision affecting a real patient.